First of all, you may be wondering what mesothelioma is, and why I should be scared of it ?.....

Mesothelioma

Mesothelioma is the medical name for cancer of the lung, and is usually caused by exposure to asbestos. Symptoms my not appear for up to 50 years or so after exposure to asbestos, and people who haven't had any contact with asbestos for many years, are now showing signs of having this deadly disease. The symptoms are usually shortness of breath, coughing, and chest pains and feeling very tired.

Why should I be scared of it ?

As a small child, I used to live near a factory which used asbestos to make fire-proof products and other insulating materials for the building industry. I believe that asbestos was also used in the manufacture of break linings. I can remember seeing the asbestos dust that spewed out of the factory covering the surrounding area (including part of our school playground) with this deadly snow like powder. Of course, as we were just kids at that time, we had absolutely no idea just how deadly this dust was. We even played in it completely unaware of its dangers.

The Horror Came Later.

It wasn't until years later after the factory had been closed down, that we began to see the full horrors of this white snow looking powder, we had played with as children. By this time I was much older, and the dangers of asbestos had been given massive coverage by the media, so I was now aware of what could happen to myself and hundreds of other people who lived in the same area as this factory in years to come.

TV Documentary.

This factory received national television coverage, and on one program they interviewed families who had suffered due to the problem of asbestos. I was shocked to see that I knew some of the people who had lost family members due to developing mesothelioma, in fact I actually went to school with some of the people who took part in the program. The program showed old photographs of the area around the factory (including my old school) covered in powder, and it really did look like it had been snowing. When you see all of this on television it really does make you just a little bit worried, especially when you have been in contact with asbestos like I have.

Treatments.

If mesothelioma is diagnosed early enough, a cure is possible with a combination of surgery, chemotherapy, and radiation. However, in the case of a more advanced illness a cure is not possible, but with the right treatments the illness can be slowed down dramatically and medication can be used to ease any pain.

X-Rays.

As a precaution I did have x-rays a few years ago just to put my mind at rest, and thankfully they were all clear. The doctor recommended that I should have x-rays on a very regular basis just to be on the safe side. So, at the moment everything is ok, but I will always be just a little bit worried of what might happen in the future.
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Of all the cancers caused by asbestos dust (mesothelioma), pericardial mesothelioma is the most rare, accounting for a fraction of all cases (5%). It is a cancer that grows on the pericardium (the lining of the heart). This is a delicate 'film', and any infection on the pericardium can have deadly consequences.

Once an individual has been diagnosed with pericardial mesothelioma they are offered three different treatment options. These are radiation, surgery and chemotherapy. Pericardial mesothelioma is extremely difficult to treat (due to the intricacies involved in removing the tumours from the pericardium), and a patient's chances of survival are slim. All three methods have a poor success rate mainly due to the fact that pericardial mesothelioma is detected in the mature stages of development. (The reason for this is because in the early stages of the cancer the symptoms resemble those of diseases such as pneumonia). The prognosis for a patient undergoing treatment at this point (mature stage) is usually less than a year.

Before treatment, the patient requires a doctor's evaluation in order to determine which of the three treatments are suitable for him/her. Details such as age, weight, medical history, and general well-being are considered prior to the commencement of treatment. So, how do you treat pericardial mesothelioma ?

Radiation - As with all cancer treatments that use this method, large doses of radiation are used to kill the cancerous cells on the pericardium. The downside to radiation treatment is that not only are you killing off the cancerous cells, but you are also damaging the vital organs in close proximity to the heart, namely the lungs. The heart also gets damaged (due to the large doses of radiation).

Surgery - We can break this down into two parts; aggressive surgery and palliative procedures. Aggressive surgery involves the removal of the cancerous cell. Since these are very close to the heart and lungs, this makes it an extremely precarious procedure and one that requires an extremely skilled surgeon. Palliative procedures are used in the latest of stages of pericardial mesothelioma and serve the sole purpose of reducing the symptoms. Usually at this stage the cancer is practically incurable.

Chemotherapy - This is the most widely-used of cancer therapies which involves the use of drugs to kill the cancerous cells. Unfortunately, the majority of drugs used have a low success rate with pericardial mesothelioma. Research is being conducted to come up with a cocktail of drugs that have a more favourable outcome.

There does exist another form of treatment which involves using all three aforementioned treatment options. It is known as Dual Therapy. Surgery is used to remove the cancerous cells, then chemotherapy and radiation are used to kill the remaining cells. The success rate for this method is higher than just using radiation, surgery or chemotherapy alone, but can still be dangerous. Read More...

What is mesothelioma?

The pericardium is the mesothelial tissue that surrounds and acts as a safeguard to the heart. The pleural mesothelium membrane covers the lungs and chest cavity and peritoneum is the mesothelial tissue that enfolds the organs in the abdominal cavity.

What is actually cancer mesothelioma?

Mesothelioma is a type of cancer that affects the mesothelium, a dual layered membrane with which our chest, lungs, abdomen and the heart is wrapped safely.

Cancer Mesothelioma can damage any of these cells, although pleural mesothelioma is more common; it metastasizes and at an advanced stage the disease reach to the other parts of the body like the lymph nodes, lungs, chest wall, or abdominal organs.

How is cancer mesothelioma caused?

Though asbestos exposure is the primary reason in 70% to 80% of the cases, mesothelioma can be caused by other means, like exposure to the chemical zeolite that is also present in asbestos.

Asbestos has become part of our daily life being in cement, brake linings, roof shingles, flooring products, textiles, and insulation. The asbestos fibers take their toll by going into our windpipe and settling in the internal organs causing the formation of carcinogenic tumors.

The overall scenario regarding cancer mesothelioma

Though there is a ban on certain asbestos products, around 1000 people in France and above 2000 people in the U.S are faced with this nightmare each year.

Mostly, workers from shipyards, asbestos mines and mills are prone to this mishap, due to a constant exposure to asbestos. However, it takes 30 to 50 years for the disease to surface and show symptoms though they are not always accurate.

Cancer mesothelioma is proving more than a menace and the average person live for 12-24 months; the earlier it is

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As with any cancer, treatment for Mesothelioma depends on the location of the cancer, the progression of the disease, the age as well as state of health of the patient.

It is the oncologist who specializes in the disease who will decide on the line of treatment. The disease is difficult to treat and in most cases the prognosis is poor. Treatment options include:

1. If the diagnosis is done in the early stages surgery may be recommended to remove all cancerous tissues. This means thoracoscopy, VATS or video assisted thoracic surgery, mediastinoscopy (used for staging), or laproscopy. Often, doctors will advise palliative procedures like chest tube drainage and pleurodesis, thoracoscopy and pleurodesis, pleuroperitonial shunt, or pleurectomy, which treat the symptoms of mesothelioma rather than the disease.
2. Radiation is prescribed aggressively for mesothelioma patients and is often given in combination with surgery or in order to control symptoms, palliatively. Research on using radiation therapy using implants or UV light therapy is in progress as traditional radiation therapy damages surrounding healthy tissue.
3. Chemotherapy is an option and around 12-20% of patients respond to the drugs. Anti-cancer drugs destroy cancer cells and prevent their spread. In mesothelioma, chemotherapy is not considered to be curative. The aim is to prevent spread of the disease; shrink the tumor prior to surgery, known as neoadjuvant therapy; to annihilate any remains of the tumor in the body post surgery; and to relieve pain and other discomfort, palliative chemotherapy. Experts recommend prescribing premetrexed along with cisplastin. These drugs have shown positive results and this is now standard care for Mesothelioma not treatable by surgery.
4. Biological therapy using interleukin 2.
5. Immunotherapy where the body’s own immune system is stimulated to fight the disease. Biological response modifiers, BRMs, are used in treatment. These enhance the functions of the immune system; regulate metabolic reactions that promote growth of cancers; alter cancer cell division; block or reverse processes that lead to formation of cancers; and prevent spread of cancer.
6. Gene therapy, where attempts are made to correct the gene sequence that causes the cancer. This is of two kinds, replacement gene therapy and knockout gene therapy.
7. Administration of lovastatin, a cholesterol lowering drug.
8. Photodynamic treatment where a photosensitive medication is activated using a laser. This is done during the surgical removal of cancerous tissues.
9. Draining of fluid in the chest or abdominal cavity followed by introduction of medications into the cavity to prevent fluid accumulation is done for patients who have uncontrolled fluid accumulation and intense discomfort stemming from it.
10. Combination therapy or Trimodal therapy which means surgery accompanied by radiation and chemotherapy.

Often, complementary medicines are also used. Termed to be holistic this kind of treatment focuses on a patient’s physical, mental, emotional, and spiritual well being.

In the case of Mesothelioma which is untreatable one can opt for clinical trials of new treatments that are in progress in several research laboratories and centers. The best advice on the line of treatment would be that recommended by the oncologist or physician.
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